ESA	Initial dose	Dose adjustment
Epoetin alfa and beta	Non-dialysis CKD: ~50 U/kg once or twice weekly (or up to 100 U/kg every 2 wk) CKD G5D: 50–100 U/kg 3× weekly	Non-dialysis: adjust dose/frequency as needed (not more than once weekly) G5D: ↑25 U/kg/dose if Hb rise <1.0 g/dL after 4 wk; ↓10–25 U/kg/dose if Hb rise >2 g/dL in 4 wk
Erythropoietin biosimilars	Product names and doses vary by region — refer to individual product information
Darbepoetin	Non-dialysis CKD: 0.45 µg/kg weekly or 40–100 µg every 2–4 wk CKD G5D: 0.45 µg/kg weekly or 0.75 µg/kg every 2 wk	Non-dialysis: adjust as needed (not more than once weekly) G5D: ↑25% if Hb rise <1.0 g/dL after 4 wk; ↓25% if Hb rise >2 g/dL in 4 wk
Methyl polyethylene glycol–epoetin beta (CERA)	Non-dialysis CKD: 0.6 µg/kg or 50–120 µg every 2 wk, or 1.5 µg/kg or 120–200 µg/kg monthly CKD G5D: 0.6 µg/kg every 2 wk	Non-dialysis: adjust as needed (not more than every 2 wk) G5D: ↑30–50 µg/dose if Hb rise <1.0 g/dL in 4 wk; ↓30–50 µg/dose if Hb rise >2 g/dL in 4 wk

Weight-based dosing used for children. Refer to product labelling for conversion from one ESA to another.